Charles Osborne damaged a pin-sized blood vessel in his brain in 1922. As a result, he had hiccups non-stop for approximately 68 years, just one year before his death in 1991.
Charles Osborne was carrying heavy objects one day when he fell down. "I fell but felt nothing", he recalled. He was later told by his doctor he "bust" a pin-sized blood vessel in his brain. Dr Terence pointed out the tiny blood vessel turned out to be be part of the brain that inhibited hiccup responses, and as a resulted he hiccuped non-stop for 68 years, which peaked to about 40 times per minute but gradually reduced to 20 times per minute.
It was estimated that he hiccuped over 340 million times in his life! However, this had not seemed to interfere with his eating or drinking and he even learned a technique to keep the hiccups silent.